Whats the "best" self defence strike/submission to use against a Crack cocaine/PCP drug addict :) ?

people who are drugged out of their minds are usually unable to feel pain, best way would be to get out of the situation, or choke them out, because chokes aren't pain techniques but they cut off oxygen, and blood flow to the brain, you can break their arms, damage their joints, ect ect, and they may still come at you but if you choke them out they are out. and you'll have plenty of time to get away.